Unveiling the Partners of the DRBD2-mRNP Complex, an RBP in Trypanosoma Cruzi and Ortholog to the Yeast SR-protein Gbp2

Published in BMC Microbiology, 2019

Recommended citation: Wippel HH, Malgarin JS, Inoue AH, et al. Unveiling the partners of the DRBD2-mRNP complex, an RBP in Trypanosoma cruzi and ortholog to the yeast SR-protein Gbp2. BMC Microbiol. 2019;19(1):128. Published 2019 Jun 11. doi:10.1186/s12866-019-1505-8 https://pubmed.ncbi.nlm.nih.gov/31185899/

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RNA-binding proteins (RBPs) are well known as key factors in gene expression regulation in eukaryotes. These proteins associate with mRNAs and other proteins to form mRNP complexes that ultimately determine the fate of target transcripts in the cell. This association is usually mediated by an RNA-recognition motif (RRM). In the case of trypanosomatids, these proteins play a paramount role, as gene expression regulation is mostly posttranscriptional. Despite their relevance in the life cycle of Trypanosoma cruzi, the causative agent of Chagas' disease, to date, few RBPs have been characterized in this parasite.